KPV
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KPV is a synthetic tripeptide consisting of Lysine, Proline, and Valine. It represents the C-terminal amino acid sequence (11-13) of the endogenous alpha-Melanocyte Stimulating Hormone (α-MSH). Research indicates that while this fragment lacks the pigment-inducing melanotropic activity of the full hormone, it retains significant anti-inflammatory properties, specifically investigated in models of gastrointestinal and dermatological inflammation.
For Research Use Only. Not for human consumption.
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KPV Research Peptide Reference Material
ANALYTICAL REFERENCE STANDARD: Synthesized tripeptide sequence supplied for in vitro assay development, biochemical pathway mapping, and preclinical evaluation. Baseline purity threshold ≥99% verified via high-performance liquid chromatography (HPLC). Strictly for laboratory research use only.
Molecular Structure & Background Hierarchy
KPV is a naturally occurring tripeptide fragment with the molecular formula C₁₆H₃₀N₄O₄. It corresponds to the specific amino acid sequence Lys-Pro-Val. This sequence is derived from alpha-Melanocyte Stimulating Hormone (α-MSH), a peptide known for its role in pigmentation and energy homeostasis. However, the KPV fragment is distinct in that it does not bind to the melanocortin receptors responsible for melanogenesis, allowing researchers to study its anti-inflammatory potential in isolation.
NF-κB Signaling & Cellular Transport Mechanics
Scientific studies focus extensively on KPV’s ability to modulate the NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) signaling pathway. In laboratory models, KPV has been observed to translocate into cells via the PepT1 peptide transporter, where it may downregulate the expression of pro-inflammatory cytokines. This molecular mechanism is of particular interest in research models evaluating structural gut wall integrity, Inflammatory Bowel Disease (IBD), and experimental colitis.
Antimicrobial & Cutaneous Investigation Vectors
Additionally, KPV is investigated for its potential antimicrobial activity. Studies suggest that the peptide may disrupt the structural integrity of fungal and bacterial cell membranes. In dermatological research, KPV is utilized to examine epithelial wound healing rates and the reduction of contact dermatitis, promoting the study of peptide-based modulation of the host immune response without the variables or side effects associated with traditional steroidal compounds.
LABORATORY COMPLIANCE DIRECTIVE: This product is strictly for laboratory and research purposes only. KPV is not intended for human use, diagnostic, or therapeutic procedures. It serves as an analytical reagent for scientific study and method validation.
References
- Dalmasso, G., et al. (2008). “PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation.” Gastroenterology, 134(1), 166-178.
- Brzoska, T., et al. (2008). “Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo.” Endocrine Reviews, 29(5), 581-602.
- Luger, T. A., et al. (2003). “The role of alpha-melanocyte-stimulating hormone in cutaneous biology.” Journal of Investigative Dermatology Symposium Proceedings, 8(1), 45-52.
