Semaglutide 20mg – GLP-1 Analogue Peptide

Semaglutide 20mg is a high-purity GLP-1 receptor agonist peptide engineered for research applications. As an analog of human GLP-1 (glucagon-like peptide-1), Semaglutide is renowned for its potent effects on insulin secretion and appetite regulation. This 20mg lyophilized peptide (≥99% purity) provides researchers with a reliable compound to study pathways in type 2 diabetes, obesity, and metabolic disorders under controlled laboratory conditions.

• Third-Party Lab Verified
• Mannitol-Free Preparation
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Why Choose Semaglutide 20mg?

🔬 Proven GLP-1 Pathway Activation

Selective Incretin Agonist: Semaglutide targets the GLP-1 receptor, mimicking the natural hormone incretin effects. It robustly stimulates insulin release (glucose-dependent) and suppresses glucagon secretion, making it invaluable for research on glucose homeostasis and pancreatic function. Its well-characterized mechanism provides a clear window into GLP-1 pathway dynamics.

🍽️ Appetite & Weight Regulation

Notable Effects on Satiety: Semaglutide is widely studied for its impact on appetite and body weight. Research models have shown that activating the GLP-1 receptor can lead to reduced food intake and weight loss due to delayed gastric emptying and increased satiety signals. This makes Semaglutide 20mg an ideal candidate for investigating anti-obesity interventions and appetite-regulation mechanisms in preclinical studies.

🧪 High Purity & Stability

≥99% Purity, No Fillers: Our Semaglutide is produced at research-grade purity (HPLC-verified ≥99%), ensuring consistent performance in experiments. The preparation is excipient-free – no mannitol or glycine buffers – which means your assays won’t be confounded by impurities or fillers. Each batch comes with a Certificate of Analysis confirming identity and purity, so you can proceed with confidence in your results.

⏱️ Long-Acting Analogue

Extended Activity: Semaglutide is a modified GLP-1 analogue with a prolonged half-life (achieved via amino acid substitutions and a C-18 fatty acid chain). This long-acting profile allows once-weekly dosing in vivo, which is advantageous for research requiring sustained GLP-1 receptor stimulation. In the lab, this property can be explored for its effects on chronic metabolic modulation, beta-cell preservation, and weight management over extended periods.

What Is Semaglutide?

Semaglutide is a synthetic peptide analog of the human incretin hormone GLP-1. It comprises 31 amino acids with structural modifications that confer enhanced stability and albumin binding, thus extending its active duration. Semaglutide acts as a glucagon-like peptide-1 receptor agonist, meaning it binds to and activates GLP-1 receptors in the body. This action triggers a cascade of effects familiar to diabetes and obesity researchers: increased insulin release (when blood glucose is high), decreased glucagon output, slowed gastric emptying, and reduced appetite.

In research settings, Semaglutide is used to explore and understand:

• Type 2 Diabetes mechanisms – how GLP-1 analogues improve beta-cell response, insulin sensitivity, and overall glycemic control.
• Weight loss and appetite control – evaluating its impact on hypothalamic appetite regulation, calorie intake, and body weight changes in diet-induced obesity models.
• Cardio-metabolic effects – since GLP-1 agonists like Semaglutide have shown benefits in cardiovascular outcomes, researchers can investigate effects on blood pressure, inflammation, and lipid profiles in preclinical studies.

Semaglutide has already been the subject of extensive clinical research (as it’s the active compound in FDA-approved therapies for diabetes and obesity). This makes Semaglutide 20mg a trusted reference peptide for laboratory experiments, allowing scientists to replicate and extend findings in a controlled non-human environment. Its predictable profile and significant body of literature help inform experimental design and comparative studies against newer compounds like Tirzepatide or Retatrutide.

Product Specifications

Peptide: Semaglutide (GLP-1 analog, modified human sequence)
Quantity: 20 mg per vial (lyophilized powder)
Purity: ≥99% (HPLC and Mass Spec verified)
Form: Lyophilized powder (acetate salt)
CAS Number: 910463-68-2
Molecular Formula: C₁₈₇H₂₉₁N₄₅O₅₉ (approx.)
Molecular Weight: ~4113.6 Da
Storage: Store at –20°C for long-term preservation. Protect from light and moisture. After reconstitution, keep the solution refrigerated (2–8°C) and use within 4–6 weeks.
Reconstitution: Reconstitute with sterile water or bacteriostatic water for injection. Swirl gently to dissolve. Do not shake vigorously.
Use: For research use only. Not for human consumption or therapeutic use.

Frequently Asked Questions

Q: How is Semaglutide different from Tirzepatide in research applications?

A: Semaglutide and Tirzepatide are both incretin-based peptides but with key differences. Semaglutide is a single-pathway GLP-1 receptor agonist, whereas Tirzepatide is a dual agonist (GLP-1 and GIP). In practical terms, Tirzepatide tends to produce greater combined effects on insulin release and weight reduction due to that extra GIP receptor activation. However, Semaglutide has been more extensively studied over a longer period (as it was developed earlier), giving it a large foundation of data on efficacy and safety in metabolic research. Researchers may choose Semaglutide 20mg when they want to specifically isolate the GLP-1 mediated effects or use it as a benchmark to compare against dual-agonist compounds like Tirzepatide.

Q: What are the primary research uses of Semaglutide?

A: Semaglutide is primarily used in research on type 2 diabetes and obesity. Key applications include studying glucose control (insulin secretion, beta-cell function, glycated hemoglobin changes), appetite and weight loss mechanisms (satiety signaling, calorie intake reduction, body weight outcomes), and even neuroendocrine effects (some studies explore GLP-1 analogues in brain regions involved in appetite and reward). Additionally, due to positive cardiovascular outcomes seen with GLP-1 analogs clinically, labs may investigate Semaglutide’s effects on heart and blood vessels in animal models (e.g. looking at atherosclerosis development, blood pressure, or inflammation markers). All these uses remain strictly preclinical and investigational.

Q: Does Semaglutide 20mg require any special handling or preparation?

A: Semaglutide 20mg is delivered as a stable lyophilized powder. Before use, you will need to reconstitute it with a suitable solvent such as sterile bacteriostatic water. Because Semaglutide has a larger molecular weight and fatty-acid conjugation, it may dissolve a bit slower than smaller peptides – allow it to fully dissolve by gentle swirling. Avoid exposing the peptide to repeated freeze-thaw cycles; aliquot your reconstituted solution if needed. When stored properly (dry powder at –20°C; reconstituted at 2–8°C), Semaglutide remains stable for the duration of typical experiments. Always follow laboratory safety guidelines when handling this peptide.

Q: Is this Semaglutide the same as the drug used for diabetes/weight loss?

A: It is the same active molecule, but our product is sold strictly for laboratory research, not for medical use. Semaglutide is indeed the active ingredient in certain FDA-approved medications (for example, a well-known diabetes injection and a higher-dose weight management injection). The Semaglutide 20mg from BulkGLP is synthesized to high purity for research purposes. It is not produced or labeled for human or veterinary use. Any discussion of its effects (like lowering blood sugar or reducing weight) refers to observed research outcomes. It must not be used as a drug or supplemented outside a research setting.

Ready to Advance Your Research?

Unlock new insights into metabolic health with Semaglutide 20mg from BulkGLP. With its proven GLP-1 receptor activity and our guarantee of purity and quality, this peptide is an excellent addition to any diabetes or obesity research program. Order now to take advantage of BulkGLP’s reliable supply, rigorous testing, and fast shipping – and propel your research on GLP-1 analogues to the next level.