Retatrutide (LY3437943): High-Purity Tri-Agonist for Research

BulkGLP offers premier Retatrutide (LY3437943) for laboratory and research use. As a powerful triple-agonist for the GLP-1, GIP, and glucagon receptors, Retatrutide is a cornerstone of advanced metabolic research. Every batch is third-party tested to guarantee >99% purity and is prepared without mannitol, buffers, or fillers, ensuring your results are precise and repeatable.

For Laboratory Research Use Only. This product is not for human or veterinary consumption.

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Purchase Retatrutide for Your Study

Select from single research vials, cost-effective multi-vial packs, or bulk Retatrutide powder to meet your laboratory’s specific needs.

• Single Research Vials: 5mg, 10mg, 15mg, 20mg, or 30mg
• Multi-Vial Packs: 10x10mg, 10x15mg, 10x20mg, 10x30mg (Ideal for extended studies)
• Bulk Retatrutide Powder: 100mg, 250mg, 500mg. 750mg, 1000mg/1g (For high-volume needs)

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Understanding Retatrutide: The Triple-Agonist Peptide

Retatrutide, also known by its research code LY3437943, represents a significant advancement in peptide science. Unlike previous peptides that target one or two metabolic receptors, Retatrutide is a triple-agonist, engineered to activate three distinct pathways involved in metabolism, appetite, and energy expenditure.

The Tri-Agonist Mechanism of Action

Retatrutide’s unique efficacy stems from its ability to simultaneously activate three key receptors:

1. GLP-1 (Glucagon-Like Peptide-1) Receptor: Activation of this receptor is known to enhance insulin secretion, suppress appetite, and slow gastric emptying. This is a primary mechanism for peptides like Semaglutide.
2. GIP (Glucose-Dependent Insulinotropic Polypeptide) Receptor: This receptor also contributes to insulin release but has been shown to potentially improve insulin sensitivity and regulate fat storage. It is a key target of Tirzepatide.
3. Glucagon (GCG) Receptor: This is Retatrutide’s defining feature. While glucagon is traditionally known for raising blood sugar, its activation in this context is believed to increase energy expenditure, promote satiety, and enhance fat oxidation (the burning of fats for energy).

By activating all three pathways, Retatrutide is hypothesized to create a synergistic effect, leading to more profound impacts on weight regulation and metabolic health than single or dual-agonist peptides.

Clinical Research and Potential Benefits

Phase 2 clinical trials, such as the TRIUMPH-2 study, have demonstrated Retatrutide’s potential in research settings. Studies have explored its effects on significant weight loss, glycemic control, and reduction in non-alcoholic fatty liver disease (NAFLD). These ongoing studies are essential for fully characterizing the safety and efficacy profile of the peptide.

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Retatrutide vs. Semaglutide vs. Tirzepatide

Understanding the key differences between these metabolic peptides is crucial for designing specific research experiments.

Feature	Retatrutide	Tirzepatide	Semaglutide
Mechanism	Tri-Agonist	Dual-Agonist	Single-Agonist
Receptor Targets	GLP-1, GIP, Glucagon	GLP-1, GIP	GLP-1
Unique Feature	Includes Glucagon activation for increased energy expenditure and fat oxidation.	Synergistic GIP/GLP-1 action.	Highly selective GLP-1 agonism.

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Why Buy Retatrutide from BulkGLP?

When you buy Retatrutide for your research, purity and consistency are non-negotiable. Here’s why researchers choose BulkGLP:

• Guaranteed >99% Purity: Every batch is verified by third-party HPLC analysis, with lab reports available to ensure you receive only the highest quality compound.
• No Mannitol or Fillers: Our Retatrutide is lyophilized pure. What you see is pure peptide, not stabilizing agents that can interfere with research accuracy. This ensures potent receptor activity and precise dosing.
• Reliable, Scalable Supply: From single vials for preliminary studies to bulk Retatrutide powder for large-scale applications, we provide a consistent and reliable supply chain.
• Secure and Discreet Shipping: We understand the importance of your work. All orders are shipped securely and discreetly to your laboratory.

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Format Details & Handling Notes

Proper handling is crucial to maintain the integrity of your Retatrutide peptide.

1. Retatrutide Vials (Single & Multi-Packs)

• Form: Lyophilized powder in sealed, sterile research vial(s).
• Contents: Each vial contains the specified amount (e.g., 5mg, 10mg, 30mg) of pure Retatrutide.
• Reconstitution: Ready for reconstitution with bacteriostatic water or an appropriate research solvent. Always introduce the solvent gently to avoid damaging the peptide.

2. Bulk Retatrutide Powder

• Form: Lyophilized peptide powder supplied in a sealed vial.
• Quantities: Available in 100mg, 250mg, 500mg, or custom bulk amounts.
• CRITICAL: Handling bulk powders requires a lab-grade environment and equipment (such as a milligram scale) for accurate aliquoting without contamination.
• Safety Note: This powder is extremely fine. To prevent inhalation, work in a well-ventilated area and use personal protective equipment (PPE) like a mask and gloves.

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Product Specifications

• Product Name: Retatrutide
• Synonyms: LY3437943, GGG Tri-Agonist
• Purity: >99% (Verified by Third-Party HPLC)
• Appearance: White lyophilized powder (may appear collapsed or fragmented, this is normal for pure peptide)
• Molecular Formula: C₂₂₁H₃₄₂N₄₆O₆₈
• Molecular Weight: ~4731.33 g/mol
• CAS Number: 2381089-83-2
• Preparation: Contains no mannitol, buffers, or fillers.

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Storage & Stability

• Before Reconstitution (Lyophilized Powder): Store in a freezer at -20°C or colder for long-term stability.
• After Reconstitution (Liquid): Store in a refrigerator at 2–8°C (36–46°F). Protect from light.
• Important: Avoid repeated freeze-thaw cycles to maintain peptide integrity.

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Frequently Asked Questions

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Legal and Safety Disclaimer

All products sold on this site, including Retatrutide (LY3437943), are intended strictly for in-vitro laboratory research and development purposes only. They are not for human or veterinary use. By purchasing this product, you confirm that you are a qualified researcher or scientist and that you will handle and use this chemical in accordance with all applicable laws and safety protocols.