The "Triple G" Agonist
Retatrutide (LY3437943) is the newest generation of research peptide, acting as a triple agonist for GLP-1, GIP, and Glucagon receptors. Our lyophilized vials are mannitol-free and third-party tested for >99% purity.
HPLC & MS Verified >99%
Pure lyophilized powder, no fillers.
Dispatched from USA inventory.
Strictly for in-vitro research use.
Product Overview
BulkGLP offers high-purity Retatrutide in various research sizes (10mg, 15mg, 20mg, and 30mg). Unlike Semaglutide (single agonist) or Tirzepatide (dual agonist), Retatrutide engages three distinct receptor pathways simultaneously.
This "Triple Agonist" mechanism has made it a primary subject of interest in metabolic research regarding obesity, insulin sensitivity, and hepatic health.
Mechanism of Action (The "Triple G")
| Receptor | Primary Research Function |
|---|---|
| GLP-1 (Glucagon-like Peptide-1) | Regulates gastric emptying and signals satiety centers in the brain. |
| GIP (Glucose-dependent Insulinotropic Polypeptide) | Potentiates insulin secretion and improves lipid metabolism. |
| GCGR (Glucagon Receptor) | Increases energy expenditure and promotes lipolysis (fat breakdown) in the liver. |
Technical Specifications
- Cas Number: 2381089-83-2
- Sequence: Modified peptide sequence with C20 fatty-acid chain.
- Molecular Formula: C221H342N48O68
- Appearance: White lyophilized powder (Freeze-dried).
- Solubility: Water soluble (Requires Bacteriostatic Water for reconstitution).
- Storage: Store at -20°C (Freezer). After reconstitution, store at 2-8°C (Refrigerator).
Research Applications
Retatrutide is currently being studied for its potential superiority over dual-agonists. In pre-clinical and Phase 2 trials, the addition of the Glucagon receptor agonist was shown to increase resting energy expenditure, a feature not present in standard GLP-1 agonists.
Looking for other metabolic peptides? Compare with our Tirzepatide Research Vials or view our full peptide catalog.
Frequently Asked Questions
What is the difference between Retatrutide and Tirzepatide?
Tirzepatide is a dual agonist (GLP-1 and GIP). Retatrutide adds a third mechanism: Glucagon receptor agonism. This third mechanism is theorized to enhance thermogenesis (calorie burning).
How do I reconstitute this peptide?
This product is sold as a lyophilized powder. Researchers typically use Bacteriostatic Water to reconstitute it. Ensure you do not shake the vial vigorously; gently swirl to dissolve.
Do you provide a COA?
Yes. Every batch is tested by an independent third-party laboratory. You can view the Certificate of Analysis (COA) for the current batch in the image gallery above or request it via email.
This product is sold strictly for laboratory research and development purposes. It is NOT for human consumption, diagnostic, or therapeutic use. BulkGLP is a chemical supplier, not a compounding pharmacy. Any orders suspected of personal use will be cancelled.